Gel Electrophoresis Reagents and Buffers
ABclonal Technology PSMC1 Rabbit pAb
The 26S proteasome is a multicatalytic proteinase complex consisting of a 20S core and a 19S regulator. The 20S core has 4 rings of 28 subunits, while the 19S regulator contains ATPase and non-ATPase subunits. Proteasomes cleave peptides in an ATP/ubiquitin-dependent process, important for class I MHC peptide processing. This gene encodes an ATPase subunit of the triple-A ATPase family with chaperone-like activity. It interacts with the hepatitis B virus X protein, critical for viral replication, and the adenovirus E1A protein, modifying proteasome activity. The subunit also interacts with ataxin-7, indicating a role in spinocerebellar ataxia type 7, a neurodegenerative disorder.
ABclonal Technology CNTN6 Rabbit pAb
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants.
ABclonal Technology SOX13 Rabbit pAb
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.
ABclonal Technology CHMP7 Rabbit pAb
Involved in several processes, including late endosome to vacuole transport, midbody abscission, and mitotic nuclear division. Located in cytosol, nuclear envelope, and nucleoplasm. Part of ESCRT III complex. Colocalizes with chromatin.
ABclonal Technology CDK19 Rabbit pAb
This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
ABclonal Technology PAH Rabbit pAb
This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase protein family. The encoded phenylalanine hydroxylase enzyme hydroxylates phenylalanine to tyrosine and is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria.
ABclonal Technology SAMD3 Rabbit pAb
SAMD3 (Sterile Alpha Motif Domain Containing 3) is a Protein Coding gene. Diseases associated with SAMD3 include Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma. An important paralog of this gene is CNKSR2.
ABclonal Technology CALM3 Rabbit pAb
This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene.
ABclonal Technology WBSCR27 Rabbit pAb
This gene encodes a protein belonging to ubiE/COQ5 methyltransferase family. The gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.22-q11.23.
ABclonal Technology WDR33 Rabbit pAb
Predicted to be involved in mRNA polyadenylation. Predicted to act upstream of or within mRNA processing. Located in nucleus. Orthologous to human WDR33 (WD repeat domain 33).
Cayman Chemical CYP1AfIsh PolycLNal ntIb 500uL
An ATP-competitive inhibitor of Hsp90 that causes degradation of client proteins resulting in cell cycle arrest or apoptosis orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice
ABclonal Technology PROZ Rabbit pAb
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.
ABclonal Technology BCR Rabbit pAb
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology KCNJ15 Rabbit pAb
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene.